ASEF Podcast (SLO): Leading the Future of Neuroscience: Jernej Ule’s Research Journey [Episode #50]

Hosted by Zara Bunc, this episode of the ASEF Podcast features Prof. Dr. Jernej Ule, a leading expert in molecular and neuroscience, Director of the UK Dementia Research Institute (UKDRI) at King’s College London, and head of research groups at the National Institute of Chemistry and the Francis Crick Institute.

Jernej Ule shares his academic journey, his motivation for studying the brain and neurodegenerative diseases, and provides a deep dive into the development of the CLIP method for studying protein-RNA interactions. The discussion also covers the differences between academic and industry careers, the importance of mentorship and leadership in research teams, and emerging therapeutic approaches for neurodegenerative disorders.

The episode begins with Ule’s early philosophical influences and chance encounters that led him to molecular neuroscience during his studies in Ljubljana. He then explains the complexity of neurodegenerative diseases, what drives researchers forward despite setbacks, and the choices involved in pursuing an academic career versus industry.

A major focus is on the CLIP method, developed during his doctoral work at Rockefeller University in New York, which has enabled precise mapping of protein-RNA interactions. Professor Ule also introduces the discovery of the interstase, a new cellular mechanism, and discusses its implications for understanding cell biology and developing novel therapies for ALS and other neurodegenerative diseases.

Other highlights include insights on leading multiple research teams across different countries, the art of scientific inquiry, and practical advice for early-career researchers navigating the decision between academia and industry.